Gene and Genome Parameters of Mammalian Liver Circadian Genes (LCGs)
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چکیده
منابع مشابه
Gene and Genome Parameters of Mammalian Liver Circadian Genes (LCGs)
The mammalian circadian system controls various physiology processes and behavior responses by regulating thousands of circadian genes with rhythmic expressions. In this study, we redefined circadian-regulated genes based on published results in the mouse liver and compared them with other gene groups defined relative to circadian regulations, especially the non-circadian-regulated genes expres...
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Circadian clocks are endogenous oscillators driving daily rhythms in physiology. The cell-autonomous clock is governed by an interlocked network of transcriptional feedback loops. Hundreds of clock-controlled genes (CCGs) regulate tissue specific functions. Transcriptome studies reveal that different organs (e.g. liver, heart, adrenal gland) feature substantially varying sets of CCGs with diffe...
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Circadian (daily) rhythms are found in most living organisms from cyanobacteria to mammals. They are generated by an internal ‘clock’ that is reset by external time cues and that regulates a variety of physiological functions through downstream target genes. Analysis of the mammalian transcriptome using DNA microarrays is now identifying hundreds of tissue-specific clock-controlled genes, which...
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Albrecht, Urs. Invited Review: Regulation of mammalian circadian clock genes. J Appl Physiol 92: 1348–1355, 2002; 10.1152/japplphysiol. 00759.2001.—The circadian clock is a self-sustaining oscillator that has a period of 24 h and controls many physiological and behavioral systems. This clock can synchronize itself to changing environmental conditions to optimize an organisms performance. The un...
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CLOCK is a positive component of a transcription/translation-based negative feedback loop of the central circadian oscillator in the suprachiasmatic nucleus in mammals. To examine CLOCK-regulated circadian transcription in peripheral tissues, we performed microarray analyses using liver RNA isolated from Clock mutant mice. We also compared expression profiles with those of Cryptochromes (Cry1 a...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0046961